The worldwide specialist in hair health

Últimos artículos

Keys to protect your hair from the sun Keys to protect your hair from the sun
The damaged hair can be reconditioned so that it seems temporarily healthy, but it is very complicated to repair [...]

REDENHAIR ANTI GREY HAIR TREATMENT: PROVED RESULTS BY A CLINICAL STUDY REDENHAIR ANTI GREY HAIR TREATMENT: PROVED RESULTS BY A CLINICAL STUDY
Yes… you have read well! Finally, it is possible to consult the clinical study results of the ANTI-GREY HAIR T [...]

Argan stem cells: the first active capable of protecting the cells of the scalp. Argan stem cells: the first active capable of protecting the cells of the scalp.
All plants have stem cells. But, unlike animal cells, each plant cell has the potential to be modified in the form [...]

TRICO-HYAL® NUCLEUS, THE ACTIVE INGREDIENT OF REDENHAIR'S ANTIGRAY LOTION TRICO-HYAL® NUCLEUS, THE ACTIVE INGREDIENT OF REDENHAIR'S ANTIGRAY LOTION
The capillary color depends to a great extent on its melanin content, the natural pigment that forms in the melanocytes.

CHROMAFEND ™ BIOFUNCTIONAL, LINEN EXTRACT PRESERVES THE HAIR NATURAL PIGMENT CHROMAFEND ™ BIOFUNCTIONAL, LINEN EXTRACT PRESERVES THE HAIR NATURAL PIGMENT
The loss of the hair's own color is a clear sign of aging and worries to the human being since ancient times.

MELITANE ™, ACTIVE PRINCIPLE OF REDENHAIR ANTIGRAY LOTION MELITANE ™, ACTIVE PRINCIPLE OF REDENHAIR ANTIGRAY LOTION
Although gray hair can be a temporary fashion and worn elegantly, most people want hair that looks bright, natural [...]

WHAT HAPPENS WHEN IS ANTI-GRAY HAIR REMOVED WHAT HAPPENS WHEN IS ANTI-GRAY HAIR REMOVED
The popular belief that removed a cane makes you grow more is totally globalized. However, it is a false myth.

GREYVERSE™, ACTIVE PRINCIPLE OF REDENHAIR ANTI-GREYING RITUAL GREYVERSE™, ACTIVE PRINCIPLE OF REDENHAIR ANTI-GREYING RITUAL
The appearance of grey hair is an important cosmetic concern which affects both sexes and can happen at any age [...]

REDENHAIR ANTI-GREY SHAMPOO, STOP AND REVERSE THE CANAS TRAINING PROCESS REDENHAIR ANTI-GREY SHAMPOO, STOP AND REVERSE THE CANAS TRAINING PROCESS
Have you begun to notice the appearance of grey hair? Are you someone who doesn't like grey hair?

ANTI-GREYING LOTION, STOPS AND REVERSES THE CAPILLARY ENCOURAGE PROCESS. ANTI-GREYING LOTION, STOPS AND REVERSES THE CAPILLARY ENCOURAGE PROCESS.
When the process of hair graying begins to be noticed, it is vital to start acting.

What is hair miniaturisation? What is hair miniaturisation?
Hair miniaturisation is a natural process that occurs in 95% of cases of hair loss.

Stages of the hair growth cycle Stages of the hair growth cycle
As new hair is generated in the follicle it pushes the stem and creates a lengthening of the hair.

Specials

GREYVERSE™, ACTIVE PRINCIPLE OF REDENHAIR ANTI-GREYING RITUAL

Pubicado el : 04/29/2019 23:59:48
Categorias : hair-care

The main causes of grey hair formation include excessive exposure to UV rays, genetic factors, stress, nutritional deficiencies and abuse of hair chemicals.

To correct this problem, an active cosmetic ingredient has been developed which acts directly in the stimulation of melanogenesis and in the halting of melanin loss. This ingredient is GREYVERSE™, developed in mid-2018 and already winner of the BEAUTY INDUSTRY AWARDS as the best ingredient for hair care.

WHAT IS GREYVERSE™?

Greyverse™ is the result of a wide selection of several peptides tested in different biological targets which are involved in the process of hair greying. It is a palmyryl tetrapeptide (4 amino acids united in palmitic acid), whose active sequence is derived from the structure of α-MSH, known to be the main molecule which is capable of stimulating melanin formation, called melanogenesis.

As an α-MSH analogue, Greyverse™ is capable of binding to MC1-R, a transmembrane receptor located on the surface of the melanocytes. With the activation of MC1-R, this receptor stimulates the melanogenesis process, as well as the expression and activity of the catalase, which reduces the accumulation of hydrogen peroxide (H2O2) as an accelerating element of the grey hair formation process.

 

HOW DOES GREYVERSE™ WORK?

Due to its complete mechanism of action, Greyverse™ can act simultaneously and efficiently on the two main factors which cause the hair greying process:

-          It stimulates melanogenesis to increase the production of melanin in the follicles and to favour a better transfer which leads to the repigmentation of hair.

-          It reduces oxidative stress by increasing the expression and activity of the catalase, thus decreasing the accumulation of hydrogen peroxide, which maintains the complete colour of the pigment.

Unlike skin melanocytes, which if stimulated are able to produce a greater amount of melanin than the constitutive colour of the skin (facultative pigmentation), the melanocytes of the hair cannot produce more than they are genetically programmed to (only constitutive pigmentation). Therefore, Greyverse™ can only help the hair recover its natural colour and cannot obscure it.

EFFECTIVENESS STUDIES PROVE THE CAPABILITY OF GREYVERSE™

IN VITRO EFFECT OF GREYVERSE™ ON THE SYNTHESIS OF MELANIN IN HUMAN MELANOCYTES

The pigmentation of the hair is due to the presence of a pigment, melanin, secreted by the melanocytes located in the hair bulb and then transferred to the surrounding keratinocytes. The appearance of grey hair is a phenomenon directly related to the lack of melanin in the hair bulb.

In this study, the activity of Greyverse™ was investigated by measuring its effects on melanin production in a culture of human melanocytes. It was found that with only 0.5% of Greyverse™ in the formulation, and after 72 hours of treatment, the synthesis of melanin was significantly increased by 19%, improving the repigmentation of the grey hair.

 

EX VIVO EFFECT OF GREYVERSE™ ON PIGMENTATION IN HUMAN HAIR FOLLICLES

Melanosomes are generally divided into four stages of maturation determined by their structure and the quantity, quality and disposition of the melanin produced. The aim of this study was to determine the effects of Greyverse™ on the pigmentation of isolated human grey hair follicles.

To this end, the biogenesis of the melanosome of the hair was tested by testing different concentrations of this active ingredient in a scalp plasty of a 71-year-old Caucasian woman who originally had dark hair. After 7 days, melanosome protein expression increased, especially in the upper sheath and in the area of the bulb, a place of melanocyte stem cells, demonstrating an improvement in the melanosome maturation, necessary for an optimal transfer.

It was concluded that Greyverse™ promotes hair pigmentation by increasing the transfer of melanosomes and the synthesis of melanin, preferably of the eumelanin type.

IN VITRO EFFECT OF GREYVERSE™ ON THE TRANSFER OF MELANOSOMES IN A COCULTURE OF KERATINOCYTES AND MELANOCYTES

Hair pigmentation can be influenced by the concentration of melanin, as well as by the number, size and distribution of melanosomes around the keratinocyte nucleus. The transfer of melanin from melanocytes to keratinocytes is a critical step in hair pigmentation, which depends on various parameters.

In this study, the potential pro-pigmentation effect of Greyverse™ was evaluated in a co-culture of normal human epidermal keratinocytes (NHEK) and normal human epidermal melanocytes (NHEM).

The concentration of 0.005% of Greyverse™ was tested and, after 72 hours of treatment, the transfer of melanosomes between the melanocyte and keratinocyte cells was significantly increased to 50%. This shows that this active ingredient stimulates the transfer of melanosomes, which increases the melanin content in the hair shaft and leads to the natural recovery of hair pigmentation.

EFFECT OF GREYVERSE™ TUBE IN THE ENZYMATIC ACTIVITY OF CATALASE

Recent studies have shown that a deficiency of catalase, an enzyme which allows the transformation of hydrogen peroxide into oxygen and water (2H2O2 → 2 H2O + O2) in human hair follicles, contributes greatly to hair greying.

In addition, it has been proven to induce a change in the conformation of the structure of tyrosinase, synthesised by the melanocytes of the hair follicle, especially by the oxidation of the methionine residues of this key enzyme in the production of melanin. This structural modification of tyrosinase leads to a loss of its enzymatic activity and stops the synthesis of melanin in the melanocytes of the hair follicle.

The objective of this study was to determine the direct effect of Greyverse™ on the activity of catalase, measuring the amount of H2O2 which was not degraded by the enzyme.

The activity of catalase was evaluated using the catalase assay kit and it could be demonstrated that Greyverse™ is able to significantly increase the activity of catalase by 7.5%. This reduces the hair greying process caused by the oxidative stress induced by H2O2.

CLINICAL STUDIES PROVE THE EFFECTIVENESS OF GREYVERSE™

The clinical evidence of the effect of this active ingredient is the most important argument, especially for applications such as the reversion of hair colour.

Greyverse™ was tested in selected volunteers with premature greying (between 35 years of age and more than 20% grey hair) and demonstrated to decrease the overall whiteness of hair and darken grey hair after 3 months of treatment, with remarkable results which were very visible: a reduction of 30% in grey density was achieved.

As a biological process, the process of hair greying involves several genes. The evaluation of gene expression and the synthesis of related proteins is an innovative way to demonstrate the efficacy of the product.

Based on an analysis of hair pulled from several volunteers, Greyverse™ demonstrated its ability to modulate some of the main genes involved in pigmentation:

-          The increase in the expression of the MC1-R gene increases the number of receptors responsible for the induction of melanogenesis.

-          The decrease in the expression of a competitor gene of α-MSH (ASIP) to bind to MC1-R favours the activation of this reception by α-MSH to induce better melanogenesis.

-          The increase in the expression of the MITF gene, which stimulates the synthesis of melanin.

 

WHERE TO FIND GREYVERSE™?

After reading about this ingredient and the revealing efficacy and clinical studies of the tetrapeptide of palmitate, you will most certainly want to know where to find it. Because it is an exclusive ingredient to treat the appearance of grey hair, you can locate it in our intensive treatment products ANTI-GREY LOTIONANTI-GREY SHAMPOO AND HAIR NUTRITION SUPPLEMENT by REDENHAIR. In addition to this powerful ingredient, they also contain HYAL® TRIC NUCLEUS, REDENSYL®, BIOFUNCTIONAL CHROMAFEND™, MELITANE™, panthenol and niacinamide, whose combination provides the most beneficial effect for hair health, the disappearance of grey hair and the stopping of hair loss.

The continuous innovation and our great team of experts achieve maximum efficiency of our ingredients; for this reason we are pioneers in the development of products to treat hair loss.

And remember... Every month we carry out raffles and exclusive offers in our Social Networks! So follow us on Instagram or Facebook and enjoy our promotions.

Artículos relacionados

Compartir este contenido

Debe estar registrado

Haga clic aquí para registrarse

Añadir un comentario

Al publicar comentarios en la página se harán públicos tus datos en nuestra web tras haber sido validados previamente por el administrador de la web. Puedes revocar el consentimiento, ejercer tus derechos de acceso, rectificación, supresión, oposición, limitación del tratamiento y portabilidad escribiéndonos a info@redenhair.com. Más información en la Política de Privacidad

CUSTOMER
CARE
(+34) 931 700 048
100% SAFE
ONLINE PAYMENT
GUARANTEED
RETURNS
SHIPPING IN
24-48h
GIVE US YOUR PHONE AND WE CALL YOU
Trataremos tus datos para ponernos en contacto contigo y atender tus peticiones de información. Puedes ejercer tus derechos de acceso, rectificación, supresión, oposición, limitación del tratamiento y portabilidad escribiéndonos ainfo@redenhair.com. Más información en la Política de Privacidad